A brief review is given of the continuous spontaneous localization (CSL) model, in which a classical field interacts with quantized particles to cause dynamical wavefunction collapse. One of the model's predictions is that particles “spontaneously” gain energy at a slow rate. When applied to the excitation of a nucleon in a Ge nucleus, it is shown how a limit on the relative collapse rates of neutron and proton can be obtained, and a rough estimate is made from data. When applied (...) to the spontaneous excitation of 1s electrons in Ge, by a more detailed analysis of more accurate data than given previously, an updated limit is obtained on the relative collapse rates of the electron and proton, suggesting that the coupling of the field to electrons and nucleons is mass proportional. (shrink)

An attempt to discover what can be learned from the recent work of Frank Tipler on the Omega Point theory requires an analysis of his framework of understanding from scientific, philosophical, and theological perspectives. A critique of his crucial ideas, and of the salient points raised by some of his critics, can then be undertaken within the compass of his strengths. A critique of the critiques of Tipler's work allows one to evaluate the extent and limitations of his contributions.

The English critic Bentley first proposed emending the transmitted text of Troades 1109 from teget, the reading of all manuscripts, to leget. Bentley's suggestion subsequently gained wide acceptance and was printed in many later editions of the tragedies, including those of Leo , Richter , and Moricca . More recent critics have favoured retention of the manuscript reading. Carlsson, for example, underlines the distinctive alliterative quality which the reading teget imparts to the line; and the latest commentator on the Troades (...) has produced a spirited defence of the transmitted text: Andromache has not yet realized the condition of the corpse, and is thinking, not of gathering up fragmented limbs, but merely of the formal requirements of burial. What Carlsson defends on grounds of alliteration should be retained on grounds of sense: teget tumuloque tradet is a doublet of which the second part makes clear the religious meaning of the first, more general, word. (shrink)

A geometric model is proposed in which the interaction types, namely the strong, weak, electromagnetic, and gravitational interactions, are stratified in a five-dimensional manifold. The strong and electromagnetic interactions are confined to disjoint four-spaces and the weak and gravitational interactions are proposed unified in a five-manifold bounded topologically by the strong and electromagnetic four-spaces. Further, some advantages of the five-dimensional approach to current-current interactions are discussed, and a five-dimensional approach to PCAC is presented. The model is presented in hopes of (...) reconciling some contradictory lines of theoretical thought, and new fields for investigation are stressed. (shrink)

Based on concepts of self-organization, we interpret apparent motion as the result of a so-called non-equilibrium phase transition of the perceptual system with the stimulus-onset asynchrony (SOA) acting as a control parameter. Accordingly, we predict a significantly increasing variance of the quality index of apparent motion close to critical SOAs. [Shepard].

A critical discussion is provided of three central assumptions underlying Nunez's approach to modeling cortical activity. A plea is made for neurophysiologically realistic models involving nonlinearities, multiple time scales, and stochasticity.

Recent studies uncovered critical roles of the adhesion protein E‐cadherin in health and disease. Global inactivation of Cdh1, the gene encoding E‐cadherin in mice, results in early embryonic lethality due to an inability to form the trophectodermal epithelium. To unravel E‐cadherin's functions beyond development, numerous mouse lines with tissue‐specific disruption of Cdh1 have been generated. The consequences of E‐cadherin loss showed great variability depending on the tissue in question, ranging from nearly undetectable changes to a complete loss of tissue structure (...) and function. This review focuses on these studies and discusses how they provided important insights into E‐cadherin's role in cell adhesion, proliferation and differentiation, and its consequences for biological processes as epithelial‐to‐mesenchymal transition, vascularization, and carcinogenesis. Lastly, we present some perspectives and possible approaches for future research. (shrink)

This chapter describes the potential far‐reaching consequences of contemplative higher education for the fields of science and medicine.

We give a historical overview of the development of almost 50 years of empirical research on the affordances in the past and in the present. Defined by James Jerome Gibson in the early development of the Ecological Approach to Perception and Action as the prime of perception and action, affordances have become a rich topic of investigation in the fields of human movement science and experimental psychology. The methodological origins of the empirical research performed on affordances can be traced back (...) to the mid 1980’s and the works of Warren (1984, 1988) and Michaels (1988). Most of the research in Ecological Psychology performed since has focused on the actualization of discretely defined actions, the perception of action boundaries, the calculation of pi-numbers, and the measurement of response times. The research efforts have resulted in advancements in the understanding of the dynamic nature of affordances, affordances in a social context and the importance of calibration for perception of affordances. Although affordances are seen as an instrumental part of the control of action most studies investigating affordances do not pay attention to the control of the action. We conclude that affordances are still primarily treated as a utility to select behaviour, which creates a conceptual barrier that hinders deeper understanding of affordances. A focus on action-boundaries has largely prevented advancement in other aspects of affordances, most notably an integrative understanding of the role of affordances in the control of action. (shrink)

Diese Einleitung liefert eine Skizze der Genese des Bandes, eine Einführung in die im Sammelband diskutierten Themenkomplexe und Fragestellungen sowie Zusammenfassungen aller in ihm enthaltenen Beiträge.

This cutting-edge handbook brings together an international roster of scholars to examine many facets of comics and graphic novels. Contributor essays provide authoritative, up-to-date overviewsof the major topics and questions within comic studies, offering readers a truly global approach to understanding the field.

Was ist und wie funktioniert praktische Normativität? Können Soll-Sätze aus Ist-Sätzen abgeleitet werden? Gibt es so etwas wie objektive Werte und moralische Tatsachen? Oder beziehen sich normative Aussagen in Wirklichkeit auf mentale Vorgänge in den Subjekten? Welchen Geltungsanspruch haben normative Überzeugungen im Allgemeinen und moralische Überzeugungen im Besonderen? Welche Rolle spielen Wünsche, Emotionen und die (reine) praktische Vernunft? Erkennen wir moralische Regeln und Eigenschaften intuitiv? Beruht alle Moral nur auf Übereinkunft? Diese und weitere Fragen und Probleme sind heute Gegenstand einer (...) umfangreichen, interdisziplinär geführten Normativitäts-Debatte. Auf systematischer Ebene diskutieren Internalisten und Externalisten über das Wesen praktischer Gründe, Realisten und Antirealisten über den ontologischen Status praktischer Normen sowie Kognitivisten und Non-Kognitivisten über die Wahrheitsfähigkeit normativer Aussagen und die Art und Weise, wie das praktisch Gesollte erkannt werden kann. Geführt werden diese Debatten unter Rückgriff auf Positionen, die je nach Selbstverständnis der Teilnehmer aristotelisch, humeanisch, kantisch, utilitaristisch oder pragmatistisch sind. Dieser Band möchte dazu beitragen, Vertreter der unterschiedlichsten Konzeptionen praktischer Normativität in einen konstruktiven Dialog miteinander zu bringen. (shrink)

The major tenets of the recent hypothesis of punctuated equilibrium are explicit in Darwin's writing. His notes from 1837–1838 contain references to stasis and rapid change. In the first edition of the Origin (1859), Darwin described the importance of isolation of local varieties in the process of speciation. His views on the tempo of speciation were influenced by Hugh Falconer and also, perhaps, by Edward Suess (1831–1914). It is paradoxical that, although both topics were recorded in his unpublished notes of (...) 1837–1838, the second was not explicitly and fully discussed until the fourth edition of the Origin (1866). While no wholly satisfactory explanation of this paradox suggests itself, it seems probable that Falconer's work on the persistence of fossil species of elephant helped Darwin to see the wider significance of the tempo of evolution for his general theory. (shrink)

This paper reports a European Forum for Good Clinical Practice workshop held in 2011 to consider a research ethics committee training syllabus, subsequent training needs and resources. The syllabus that was developed was divided into four competencies: committee working; scientific method; ethical analysis and the regulatory framework. Appropriate training needs for each, with possible resources, were discussed. Lack of funding for training was reported as a major problem but affordable alternatives were debated. Strengths and weaknesses of this approach were discussed (...) and the resultant proposal will be disseminated through the European Forum for Good Clinical Practice and the research ethics committees of member states. (shrink)

David Lewis has complained about the truthmaker theory as a version of the correspondence theory of truth (Lewis 2001a; Lewis 2001b). His main criticism is that the truthmaker theory, if combined with the redundancy theory, is not a theory about truth, but only »about the existential grounding of all manner of other things: the flying of pigs, or what-have-you« (Lewis 2001a: 279; Lewis 2001b: 603-4). In his view, to call such a truthmaker theory a theory of truth is a »misnomer« (...) (Lewis 2001a: 279). Lewis does not claim that the truthmaker theory is false, nor does he reject it. Indeed, he expresses agreement with its spirit. But of course it would be an embarrassment to any defender of the truthmaker theory to find out that it is not about truth at all. Indeed, if it were not about truth we should »forget about the ´correspondence theory of truth´«, as the title of Lewis´ paper suggests. Therefore, it is highly desirable for any adherent of the truthmaker theory to look for an understanding of the truthmaker theory which will let it be about truth, and to see whether anything of what Lewis has said provides an argument against it. We will argue that there is such an understanding and that Lewis has not provided any material for an argument against it. (shrink)

A major shift has taken place since the 1960s concerning disclosure to patients that they have a diagnosis of cancer and that their disease is considered terminal. Full disclosure is now considered the patient's right in the United States. However, there remain many countries in which nondisclosure is still the norm. When patients from those countries are diagnosed with cancer in America, differences in attitudes and expectations can cause conflict and misunderstanding.

Die Idee zu der in diesem Band dokumentierten Tagung ist im Rahmen des disziplinübergreifenden Nachwuchswissenschaftsnetzwerkes THESIS entstanden. Der Dialog über die fachlichen und disziplinären Grenzen hinweg hat bei THESIS seit dessen Gründung im Jahre 1990 stets einen großen Raum eingenommen. Anderen Fächern Respekt und Interesse entgegenzubringen und sich nicht von stereotypen Vorurteilen leiten zu lassen, ist konstitutiver Bestandteil im Selbstverständnis des Netzwerkes. Selbstverständlich gibt es in einem solchen Verbund eine Reihe von Gelegenheiten (darunter auch den einen oder anderen entwicklungsfördernden Konflikt), (...) das eigene Bild vom Anderen und das andere Bild vom Eigenen zur Sprache zu bringen und zu hinterfragen. Auf der Basis dieser bestehenden Kommunikationsstrukturen trafen sich am 11. Oktober 2003 in Göttingen 12 junge Wissenschaftlerinnen und Wissenschaftler zwischen, über und auch auf den Grenzen ihrer eigenen Herkunftsdisziplinen, um den Trendbegriff [alpha]Transdisziplinarität" auf seine Substanz zu prüfen. (shrink)